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KMID : 0616120080390040300
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 4 p.300 ~ p.304
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The Protective Effects of Astragali Radix Against UV Induced Cellular Damage in Human Keratinocytes
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Lee Jin-Young
Park Hye-Yoon
Yeom Myeong-Hun
Kim Duck-Hee
Kim Han-Kon
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Abstract
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The root of Astragalus membranaceus Bunge (Leguminosae) has been used in the Korean oriental medicine for strengthening the vital energy. UV irradiation has been suggested as a major cause of photo aging in skin. In order to investigate protective effects against UV induced cellular damage, Astragali Radix was extracted with 70% ethanol and dissolved in DMSO. The protective effect was detected by MTT assay, LDH assay, and Comet assay in immortalized human keratinocyte cell line, HaCaT cell system after UV irradiation. Astragli Radix 70% EtOH extract reduced UV induced cellular damage in cell survival, membrane integrity and DNA damage.
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KEYWORD
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Astragalus membranaceus Bunge, human keratinocyte, UV-induced cell damage
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